Next Science is leading a paradigm shift with a unique, unprecedented approach to eradicating both biofilm bacteria and planktonic bacteria with a proprietary, non-toxic technology that disrupts the biofilm’s extracellular polymeric substance (EPS) matrix and makes the bacteria within the biofilm more vulnerable to attack by antimicrobials, antibiotics and the body’s natural immune defenses. This patented Xbio™ technology may help reduce the overall use of antibiotics and has shown no known evidence of bacterial resistance.29
Powerful. Gentle. Innovative.
Next Science believes in a healthcare world where the toughest microbial infections (bacterial, fungal, viral) are treated effectively and the microbes are unable to evade eradication through biofilms.
Additionally, treating infections should be gentle on the body and nontoxic to the environment.
Mechanism of Action
Xbio Technology, using a patented material science approach, attacks biofilm structures by breaking the strong metallic bonds that hold the EPS together. This exposes the bacteria within the biofilm and makes them more vulnerable to attack and eradication. Bacteria that are enveloped within the biofilm disruption technology then experience cell lysis through a high osmolarity imbalance across the bacterial cell membrane and wall. Xbio technology's broad spectrum efficacy helps defend from biofilm reformation.39
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Drawing on an extensive background in material science, Next Science is the leader in biofilm solutions with multiple in vitro and in vivo scientific and clinical studies, thorough safety testing, and effective technology delivery systems. Comprehensive and continuous research over time, applied to multiple applications, has resulted in the development of the most effective products for the disruption of biofilm.
Unlike other agents that claim to destroy biofilms, there is no known resistance to Next Science technology; variants are effective against any bacteria, persister cells or spores, and reduce the rate of biofilm recurrence over 100 times. 39
Next Science has created a rapid-acting technology with superior efficacy for both planktonic and biofilm bacterial forms. Xbio™ is gentle, has low toxicity and has a favorable environmental impact. Learn more about our pipeline opportunities and how we are addressing the growing problem of biofilm-caused antimicrobial resistance.
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